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The Microbiome: Why Your Gut May Be the Missing Piece in Your Health

  • Writer: Dr. Cara MacMullin, ND
    Dr. Cara MacMullin, ND
  • Apr 30
  • 3 min read

When we think about health, we often focus on symptoms like fatigue, bloating, skin issues, weight changes, brain fog, hormone imbalances, or recurring infections. But increasingly, research shows that one of the most important places to look is somewhere many people (and practitioners) overlook: the gut microbiome.


Your microbiome is the vast community of bacteria, fungi, viruses, and other microorganisms that live primarily in your digestive tract. These microbes are not just passengers, they function like a parallel organ system, influencing nearly every aspect of health.


In fact, the body hosts roughly 38 trillion microbes, with microbial genes outnumbering human genes by about 150 to 1, creating what many researchers call our “second genome.” This system helps regulate digestion, immune function, inflammation, metabolism, hormones, detoxification, mood, cognition, and even how we age .


When the microbiome is balanced and diverse, it supports resilience and health. When it becomes disrupted—a state known as dysbiosis—it can contribute to a wide range of chronic symptoms and health challenges.


Signs Your Gut May Need Attention

Gut imbalance doesn’t always show up as digestive symptoms alone. Common signs may include:

  • Bloating, gas, constipation, diarrhea, or reflux

  • Food sensitivities

  • Fatigue and brain fog

  • Anxiety, low mood, or poor focus

  • Skin issues like eczema, acne, or rosacea

  • Hormonal imbalance or PMS

  • Weight loss resistance

  • Frequent illness or poor immune resilience

  • Inflammatory or autoimmune patterns


Sometimes the gut is not the only issue, but it is often one of the foundational places to investigate.


The Gut-Brain Connection

The gut and brain are in constant communication through the gut-brain axis.

Your gut microbes help regulate neurotransmitters like serotonin, dopamine, and GABA, influencing mood, focus, motivation, sleep, and emotional regulation.


This is why microbiome imbalances may play a role in ADHD, anxiety, depression, and mood disorders, especially when digestive symptoms, inflammation, or a history of frequent antibiotic use are also present.


There is also growing research linking chronic inflammation, altered gut permeability, and microbiome imbalance to long-term cognitive decline and increased Alzheimer’s risk.


Gut Health and Immune Regulation

Nearly 70% of the immune system is located in the gut.


A healthy microbiome helps train the immune system to respond appropriately, protecting against harmful pathogens while reducing unnecessary inflammation and immune overreactions.


When the microbiome is disrupted, the immune system may become overactive (contributing to allergies, eczema, autoimmune conditions, and inflammation) or under-responsive (leading to frequent infections and poor resilience) .


This is why gut health is often deeply connected to everything from seasonal allergies to post-viral recovery or frequent infections. 


Microbiome Changes in Menopause

Hormonal shifts during perimenopause and menopause can significantly affect the microbiome—and the microbiome also influences hormone balance in return.

As estrogen changes, microbial diversity may decline, inflammation can increase, and symptoms like bloating, weight gain, poor sleep, mood changes, and insulin resistance often become more pronounced.


Supporting the microbiome during this stage can be an important strategy for improving both metabolic and hormonal resilience.


The Gut and Weight Loss Resistance

One of the most overlooked drivers of weight loss resistance is the microbiome.

When the gut is imbalanced, inflammation increases, blood sugar regulation becomes more difficult, cravings intensify, and metabolism becomes less efficient.


The microbiome also influences satiety signalling, GLP-1 activity, and insulin response, helping explain why some people feel like they are doing everything right but still struggle to lose weight.


Sometimes the issue isn’t willpower, it’s physiology.


A Root Cause Approach

Supporting the microbiome is not about taking random probiotics and hoping for the best. It starts with understanding what is driving imbalance:

  • Previous antibiotic use

  • Chronic stress

  • Poor sleep

  • Infections or post-viral changes

  • Highly processed diets

  • Low fibre intake

  • Hormonal shifts

  • Chronic inflammation


Often, the issue is not simply “bad bacteria,” but loss of microbial diversity, which means loss of important functions like vitamin production, short-chain fatty acids, immune regulation, and barrier protection .


3 Simple Ways to Support Your Microbiome Today


1. Feed Your Good Bacteria - 30+ Plants a Week 

Increase fibre-rich and polyphenol rich foods like vegetables, berries, legumes, nuts, seeds, and whole grains into your diet. Diversity in your diet helps create diversity and resilience in your microbiome.


2. Reduce What Disrupts the Gut

Highly processed foods, excess sugar, chronic stress, lack of movement, poor sleep, and unnecessary antibiotics can all negatively affect gut balance.

Sometimes healing starts with removing what is constantly irritating the system.


3. Support Your Nervous System

Stress directly impacts digestion, inflammation, and the microbiome.

Walking, proper sleep, deep breathing, slowing down meals, and time outdoors can support both gut and brain health.


The Future of Medicine Is Root Cause Medicine

The microbiome sits at the centre of many chronic health concerns.

Rather than simply managing symptoms, understanding the gut allows us to ask a better question:


Why is this happening in the first place? That is where real healing begins.


Sometimes the missing piece isn’t another supplement, it's starting with the microbiome.



 
 
 

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